Vanderbilt clinical trials center

Contact our V-ISTA team to learn more about our trials and determine your eligibility to participate in a trial. Patients: Submit the Self-Referral Form and a member of our clinical trials team will contact you. If you wish to speak with someone now, please call Referring Providers: Call our clinical trials team or submit information about your patient through our secure online referral form.

Vanderbilt-Ingram Cancer Center provides staff and investigators with the resources they need to conduct and complete scientifically meritorious clinical trials. Our Clinical Trials Office provides training resources and services to assist cancer center investigators in developing, activating and completing clinical trials. Clinical Trial Flowcharts are "maps" to help you find clinical trials applicable to various types of cancers.

Browse our open clinical trials, organized by organ system and modality. Vanderbilt-Ingram is at the forefront of promising new therapies, with access to over open clinical trials at any given time.

Through research and clinical trials, we have helped to advance the treatment of a number of cancers. Conventional clinical assays for measurement of circulating natriuretic peptides display substantial overlap, precluding determination of the basis of the relative natriuretic peptide deficiency previously observed in these groups.

We will study lean or obese, black or white, healthy adult subjects with intravenous IV saline infusion as a stimulus for natriuretic peptide production and release. We will measure circulating levels of natriuretic peptide isoforms using mass spectrometry that allows the specific identification of proBNP and its cleavage product BNP Aim 1a: The investigators will determine if galantamine inhibits NADPH IsoLG-protein adducts formation, superoxide production, and immune cell activation compared to placebo.

For this purpose, the investigators will study peripheral blood mononuclear cell PBMC , a critical source of systemic oxidative stress, collected from study participants.

Aim 1b: The investigators will determine if galantamine reduces intracellular Iso-LGs, ICAM-1, and 3-nitrotyrosine, a marker of vascular oxidative stress, in ECs harvested from study participants. Specific Aim 2: To determine if prolonged 3-month treatment with galantamine improves endothelial dysfunction as measured by vascular reactivity in AAs. The investigators will measure vascular reactivity in response to ischemia in two vascular beds: a in conduit arteries brachial artery using brachial artery diameter flow-mediated dilation FMD , and b in the microvasculature MBV using contrast-enhanced ultrasonography in skeletal muscle.

This proposal will study a novel mechanism that could alter the oxidative and immunogenic responses that contributes to endothelial dysfunction in AAs and will offer a potential pathway for the development of more effective therapies aimed at decreasing the progression of endothelial dysfunction to cardiovascular disease in this population.

Prior to randomization, subjects will be hypertensive in the absence of hypertension medication. For general questions about clinical trials, contact Research Support Services at or research. Toggle navigation Vanderbilt Clinical Trials. Search Clinical Trials Thank you for your interest in Vanderbilt research! Accepts Healthy Volunteers. Reset Search.

View Results. Participants in the study will be treated with either a study drug plus current standard of care SOC , or with placebo plus current Type: Interventional Start Date: Aug open study. Type: Observational Start Date: Oct open study. Language Development Disorders. The goal of the study is to conduct an initial efficacy study of a promising therapist and caregiver-implemented communication intervention to improve language and school readiness skills in low-income Spanish-speaking children with receptive and expressive language delays Type: Interventional Start Date: Dec open study.

Type: Observational Start Date: Feb open study. Malignant Solid Tumor. Cancer cells stick to Type: Interventional Start Date: Feb open study. The investigators will test the hypothesis that constriction of abdominal veins due to sympathetic activation Type: Interventional Start Date: Apr open study.

Please see Detailed Description Lupus Erythematosus, Systemic. A single nucleotide polymorphism SNP in this gene encodes Adipose metabolism will be measured using magnetic resonance imaging MRI scans and by aspirating a small amount of adipose Type: Interventional Start Date: Mar open study. Type 1 Diabetes. In addition, Type: Observational Start Date: Jan open study. Sjogren's Syndrome Keratoconjunctivitis Sicca.

Type: Interventional Start Date: Nov open study. Autism Spectrum Disorder. The multisite randomized control trial will include Down Syndrome Alzheimer Disease Dementia. Participants enrolled in the TRC-DS will undergo longitudinal cognitive and clinical assessment, genetic Type: Observational Start Date: Jun open study. Participants will include Type: Interventional Start Date: May open study. The goals of clinical trials include:.

Participating in a clinical trial can bring many benefits. As a patient, it can help you access new and innovative drugs or treatments still in research stages. For others, participating in a trial is a way to help advance science and health care for the public good. Vanderbilt developed and is a partner in ResearchMatch.

This national recruitment registry connects people who would like to participate in research with researchers at Vanderbilt and nationwide. Before a new treatment is tested with patients, it is carefully studied in the laboratory and tested for safety. This process identifies the new methods most likely to succeed and, as much as possible, shows how to use them safely and effectively.

At Vanderbilt, clinical trials undergo a rigorous approval process both by the U. One Vanderbilt committee reviews the study to be sure it is scientifically sound. Researchers and doctors approving a study have reason to believe that it will be as good as or better than current treatments. Patients who qualify for a trial decide with their doctor whether to participate in a study. How a treatment will work for any individual patient in the trial cannot be known ahead of time.

We discuss the risks and benefits of a study before you make a decision; this is informed consent. You will never be placed in a clinical trial without your knowledge or permission.